The README file included with the download:

PyWN("pin") - Python WordNet

WordNet is available from www.cogsci.princeton.edu/~wn

Download and install the latest wordnet distrobution.(Actually, all that
is required is an up-to-date format for the data files. PyWN is pure
Python and makes no use of the C libraries provided with wordnet.

Put each of the .py files somewhere in your python search path.

>>> from stdwn import impl
>>> synsets = impl.lookupSynsetsByForm("run")
>>> len(synsets)
52
>>> synsets[0].gloss
' a short trip'
>>> for wf in synsets[14].synonyms:
... print wf.form,
...
move go run
>>> print synsets[14].gloss
progress by being changed: "The speech has to go through several more
drafts"
>>> rels = synsets[14].relations('@') #hypernyms
>>> rels[0].gloss
' undergo a change'
>>> for wf in rels[0].synonyms:
... print wf.form,
...
change
>>> rels[0] == synsets[14].hypernym()
1
>>> more description is inside pywn.py, esp the class definitions for Synset and WordSense